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[S1‐01‐03]: Cortical thickness in Alzheimer's disease
Author(s) -
Evans Alan C.,
Lerch Jason P.,
Pruessner Jens,
Zijdenbos Alex P.,
Teipel Stefan J.,
Hampel Harald
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.057
Subject(s) - parahippocampal gyrus , linear discriminant analysis , vertex (graph theory) , white matter , psychology , nuclear medicine , pattern recognition (psychology) , medicine , mathematics , temporal lobe , artificial intelligence , computer science , neuroscience , radiology , combinatorics , magnetic resonance imaging , graph , epilepsy
efficacy of anti-amyloid therapeutics. Objective: Develop a positron emission tomography (PET) radioligand capable of non-invasively delineating and quantifying amyloid in human brain. Methods: Neutral analogs of thioflavin-T were found to possess the necessary properties of amyloid imaging radiotracers. PET imaging studies using one of these agents, carbon11-labeled 2-(4’-methylaminophenyl)-6-hydroxybenzothiazole (Pittsburgh Compound B or PIB), are currently underway at 9 PET centers throughout the world, and the evaluation of PIB as a selective amyloid imaging agent in AD and MCI subjects is ongoing. At Pittsburgh, we have completed PIB PET imaging studies in 6 AD, 10 MCI, and 8 control subjects and performed test-retest studies within 21 days in 8 subjects. A major focus of our work has been to extend the original semi-quantitative (SUV) analysis of PIB binding in human brain by using more quantitative PET methods that involve arterial blood sampling and reference tissue measures of PIB retention combined with MRI-based region of interest (ROI) identification. Analysis methods included compartmental modeling, Logan analysis with either arterial or cerebellar inputs, simplified reference tissue method, or carotid ROI input. PIB retention was assessed using the distribution volume ratio (DVR) outcome measure, which is regional DV normalized to the cerebellar reference DV. All data analysis methods evaluated provided qualitatively similar results in AD, MCI, and controls. PIB imaging studies consistently revealed markedly increased (1.5-3.0-fold) PIB DVRs in AD, relative to controls, in brain areas known to contain amyloid in AD. Heterogeneous PIB DVRs were observed in MCI subjects, which ranged from AD-like to control-like values. Test-retest variations in the same subject were in the range of 5-10%, with greater variations generally obtained for compartmental modeling than for reference tissue methods. Conclusions: Quantitative analysis methods provided consistent PIB binding measures, indicating that PIB PET is capable of delineating and quantifying amyloid in AD, MCI, and controls.