Impact of genotypic and phenotypic resistance to second-line anti-tuberculosis drugs on treatment outcomes in multidrug-resistant tuberculosis in China | Zendy

Yi Hu | Zendy; Xubin Zheng | Zendy; Zhu Ning | Zendy; Qun Li | Zendy; Zhengdong Zhang | Zendy; Sven Hoffner | Zendy

Open Access

Impact of genotypic and phenotypic resistance to second-line anti-tuberculosis drugs on treatment outcomes in multidrug-resistant tuberculosis in China

Author(s) -

Yi Hu,

Xubin Zheng,

Zhu Ning,

Qun Li,

Zhengdong Zhang,

Sven Hoffner

Publication year - 2016

Publication title -

international journal of mycobacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 20

eISSN - 2212-554X

pISSN - 2212-5531

DOI - 10.1016/j.ijmyco.2016.11.007

Subject(s) - tuberculosis , multiple drug resistance , china , drug resistance , medicine , genotype , extensively drug resistant tuberculosis , drug resistant tuberculosis , mycobacterium tuberculosis , virology , genetics , biology , gene , geography , pathology , archaeology

Despite the strong association between drug resistance and genetic mutations, the value of molecular diagnosis of drug resistance to guide the treatment of multidrug-resistant tuberculosis (MDR-TB) remains unclear. This is particularly relevant in resource-limited areas, in which it is difficult to implement the drug susceptibility test. Here, we focused on the association of drug susceptibility phenotype and genotype with treatment outcomes in patients with MDR-TB.

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