Increased detection of smear-negative pulmonary tuberculosis by GeneXpert MTB/RIF® assay after bleach concentration | Zendy

Mulualem Tadesse | Zendy; Dossegnaw Aragaw | Zendy; Leen Rigouts | Zendy; Gemeda Abebe | Zendy

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Increased detection of smear-negative pulmonary tuberculosis by GeneXpert MTB/RIF® assay after bleach concentration

Author(s) -

Mulualem Tadesse,

Dossegnaw Aragaw,

Leen Rigouts,

Gemeda Abebe

Publication year - 2016

Publication title -

international journal of mycobacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 20

eISSN - 2212-554X

pISSN - 2212-5531

DOI - 10.1016/j.ijmyco.2016.03.005

Subject(s) - genexpert mtb/rif , bleach , pulmonary tuberculosis , tuberculosis , medicine , virology , microbiology and biotechnology , immunology , pathology , biology , sputum , chemistry , organic chemistry

The GeneXpert MTB/RIF assay (Xpert) was endorsed as the initial diagnostic tool in people suspected of human immunodeficiency virus-associated or drug-resistant tuberculosis (TB). However, information regarding the performance of Xpert for diagnosing smear-negative TB in high burden settings remains limited. We evaluated the diagnostic accuracy of Xpert and the impact of bleach concentration on the performance of Xpert using smear-negative sputum samples from human immunodeficiency virus-negative patients.

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