Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacteriumsmegmatis | Zendy

JeanBosco Jouda | Zendy; Isabelle Kamga Mawabo | Zendy; Augustin Notedji | Zendy; Céline Djama Mbazoa | Zendy; Jean Nkenfou | Zendy; Jean Wandji | Zendy; Céline Nguefeu Nkenfou | Zendy

Open Access

Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacteriumsmegmatis

Author(s) -

JeanBosco Jouda,

Isabelle Kamga Mawabo,

Augustin Notedji,

Céline Djama Mbazoa,

Jean Nkenfou,

Jean Wandji,

Céline Nguefeu Nkenfou

Publication year - 2016

Publication title -

international journal of mycobacteriology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 20

eISSN - 2212-554X

pISSN - 2212-5531

DOI - 10.1016/j.ijmyco.2016.02.007

Subject(s) - garcinia , endophyte , penicillium , biology , microbiology and biotechnology , traditional medicine , botany , medicine

According to estimates by the World Health Organization, there were 9.6 million new tuberculosis (TB) cases in 2014: 5.4 million among men, 3.2 million among women, and 1.0 million among children. There were also 1.5 million TB deaths. Although there are potent anti-TB molecules, the misuse of these drugs in addition to inconsistent or partial treatment have led to the development of multidrug-resistant TB and extensively drug-resistant TB. It is established that plants harbor microorganisms, collectively known as endophytes, which also produce metabolites. Exploring the as-yet untapped natural products from the endophytes increases the chances of finding novel and active compounds. The present study was aimed to investigate the antimycobacterial activity of the crude extract and compounds isolated from Penicillium sp. endophyte associated with Garcinia nobilis against Mycobacterium smegmatis.

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