Open AccessBenzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
Author(s) -
Manoj Chandran,
Janupally Renuka,
Jonnalagadda Padma Sridevi,
Ganesh S. Pedgaonkar,
Vanaparthi Asmitha,
Perumal Yogeeswari,
Dharmarajan Sriram
Publication year - 2015
Publication title -
international journal of mycobacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 20
eISSN - 2212-554X
pISSN - 2212-5531
DOI - 10.1016/j.ijmyco.2015.02.002
Subject(s) - dna gyrase , piperazine , mycobacterium tuberculosis , chemistry , tuberculosis , microbiology and biotechnology , pharmacology , medicine , biology , biochemistry , gene , escherichia coli , pathology
Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel therapeutics. In this study, an effort was made towards the design and synthesis of benzothiazinone-piperazine hybrid analogues to obtain the possibility of it to lead development through the molecular hybridization technique.
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