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Interleukin‐6, intracellular adhesion molecule‐1, and glycodelin A levels in serum and peritoneal fluid as biomarkers for endometriosis
Author(s) -
Mosbah Alaa,
Nabiel Yasmin,
Khashaba Eman
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2016.01.018
Subject(s) - peritoneal fluid , endometriosis , medicine , gastroenterology , intercellular adhesion molecule 1 , laparoscopy , adhesion , stage (stratigraphy) , gynecology , urology , surgery , inflammation , paleontology , chemistry , organic chemistry , biology
Objective To compare levels of interleukin‐6 (IL‐6), intracellular adhesion molecule‐1 (ICAM‐1), and glycodelin A in serum and peritoneal fluid of patients with and without endometriosis, and to correlate levels with disease stage. Methods An observational study was undertaken at Mansoura University Hospital, Egypt, between March 2014 and June 2015. Patients aged 21–48 years laparoscopically diagnosed with endometriosis and those without endometriosis who underwent laparoscopy for tubal ligation were included. Levels of IL‐6, ICAM‐1, and glycodelin A were measured in samples of serum and peritoneal fluid. Receiver operating characteristic curves were used to evaluate diagnostic accuracy. Results Forty‐eight women with endometriosis and 20 without the disorder were included. IL‐6 and glycodelin A levels in serum and peritoneal fluid were higher in the endometriosis group than in the control group ( P < 0.001 for all); ICAM‐1 levels did not differ. The sensitivity and specificity values were 93.8% and 80.0% for serum IL‐6, 58.3% and 60.0% for serum ICAM‐1, and 91.7% and 75.0% for serum glycodelin A. The corresponding values for peritoneal fluid markers were 85.4% and 89.0%, 60.4% and 50.0%, and 89.6% and 90.0%, respectively. IL‐6 and glycodelin A levels in serum and peritoneal fluid increased with disease stage ( P < 0.001 for all). Conclusion IL‐6 and glycodelin A, but not ICAM‐1, are potential biomarkers for endometriosis and are positively correlated with the disease stage.