Premium
The value of chlamydial antibody level for predicting tubal blockage among women undergoing hysterosalpingography in Lagos, Nigeria
Author(s) -
Olaleye Olalekan,
Olamijulo Joseph A.
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.12.009
Subject(s) - medicine , hysterosalpingography , chlamydia trachomatis , gynecology , antibody , pelvic inflammatory disease , chlamydia , obstetrics , chlamydial infection , chlamydiales , antigen , prospective cohort study , infertility , immunology , pregnancy , genetics , biology
Objective To determine the prevalence of Chlamydia trachomatis infection among Nigerian women undergoing hysterosalpingography (HSG) and to identify any correlation between chlamydial antibody levels and a diagnosis of tubal disease. Methods A prospective cross‐sectional study was conducted from January 1 to June 30, 2013, among women scheduled to undergo HSG in the radiology department of Lagos University Teaching Hospital, Nigeria. Endocervical swabs and serum samples were collected to assess the levels of chlamydial antigen and antibody, respectively. Results Among 150 participants, 83 (55.3%) had bilateral tubal patency and 67 (44.7%) had tubal disease. Overall, 53 (35.3%) women had positive test results for chlamydial antibodies; however, none of the participants tested positive for chlamydial antigen. Women with tubal disease were more likely to test positive for chlamydial antibodies (n = 44 [65.7%]) than were those whose test results were negative (n = 9 [10.8%]; P < 0.001). The sensitivity and specificity of chlamydial antibody testing to predict tubal disease diagnosed by HSG were 66% and 89%, respectively. Conclusion The presence of chlamydial antibodies was quantitatively related to the likelihood of HSG‐diagnosed tubal disease.