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Predictive value of 4‐, 8‐, and 12‐h urine protein and protein‐to‐creatinine ratio for detection of pre‐eclampsia
Author(s) -
Haghighi Ladan,
Nasiri Nabiollah,
Ebrahimi Atefeh,
Najmi Zahra,
Moradi Yousef,
Hashemi Neda
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.11.023
Subject(s) - urine , medicine , proteinuria , excretion , creatinine , eclampsia , gold standard (test) , preeclampsia , endocrinology , pregnancy , kidney , biology , genetics
Abstract Objective To evaluate the accuracy of protein measurement and protein‐to‐creatinine ratio (PCR) in 4‐, 8‐, and 12‐h urine samples as compared with 24‐h urine samples as the gold standard method for suspected pre‐eclampsia. Methods In a prospective study, 120 women at more than 20 weeks of pregnancy with high blood pressure and no history of hypertension were enrolled between April 2010 and December 2012. Net protein excretion and PCR were evaluated in urine samples collected over 4 h, 8 h, 12 h (day), and 12 h (night) and compared with 24‐h protein excretion as the gold standard test. Results A significant positive correlation was found between the values of the 4‐h, 8‐h, 12‐h (day), and 12‐h (night) samples and the 24‐h samples. The best cutoff point of the PCR to detect significant urine protein excretion was 0.28, 0.24, 0.25, and 0.23 for the 4‐h, 8‐h, 12‐h (day), and 12‐h (night) samples, respectively. Conclusion Measurement of protein and PCR in 4‐h, 8‐h, and 12‐h urine samples might provide an alternative test for detecting proteinuria among pregnant women with suspected pre‐eclampsia when there is insufficient time to collect 24‐h urine samples.