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Prospective cohort study of persistent hypertension following pre‐eclampsia at Medani Hospital, Sudan
Author(s) -
Fadalallah Zubaida M.,
Elhassan Elhassan M.,
Rayis Duria A.,
Abdullahi Hala,
Adam Ishag
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.11.014
Subject(s) - medicine , eclampsia , prospective cohort study , incidence (geometry) , cohort , cohort study , obstetrics , pediatrics , pregnancy , genetics , physics , optics , biology
Abstract Objective To evaluate the incidence of, and factors associated with, persistent hypertension in patients with pre‐eclampsia. Methods A prospective cohort study enrolled patients presenting with pre‐eclampsia at Wad Medani Maternity Hospital, Sudan, between March 1 and October 31, 2014. Obstetric, clinical, and biochemical variables were recorded at presentation and at 6 weeks after delivery. Results Of 188 patients enrolled in the study, 6‐week follow‐up data were available for 165. Among these patients, 136 (82.4%) and 29 (17.6) had mild and severe pre‐eclampsia, respectively. At 6‐week follow‐up, 58 (35.2%) patients were experiencing persistent hypertension. Patients with persistent hypertension demonstrated significantly lower platelet counts at baseline ( P = 0.001) and neonatal weight at delivery ( P < 0.001) than patients who were normotensive at 6 weeks. Severe pre‐eclampsia was more common among patients who experienced persistent hypertension than those who were normotensive 6 weeks after delivery ( P < 0.001). In a logistic‐regression analysis, none of the investigated factors was associated with persistent hypertension; however, patients experiencing severe pre‐eclampsia were 7.3‐times more likely to experience persistent hypertension than patients with mild pre‐eclampsia (95% confidence interval 1.6–32.2; P = 0.008). Conclusion Persistent hypertension 6 weeks after delivery was common among patients who experienced pre‐eclampsia in Sudan (particularly severe pre‐eclampsia) regardless of patients' age and parity.