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Reproductive potential of mature oocytes after conventional ovarian hyperstimulation for in vitro fertilization
Author(s) -
Zhang John J.,
Yang Mingxue,
Merhi Zaher
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.08.027
Subject(s) - intracytoplasmic sperm injection , oocyte , live birth , medicine , human fertilization , in vitro fertilisation , andrology , ovarian hyperstimulation syndrome , gynecology , controlled ovarian hyperstimulation , embryo , pregnancy , biology , anatomy , genetics
Objective To compare cumulative live birth rate according to the rate of use of metaphase II (MII) oocytes in conventional ovarian stimulation protocols for in vitro fertilization (IVF) or intracytoplasmic sperm injection. Methods In a cohort study, patients aged 18–38 years undergoing their first IVF treatment at one US center were enrolled between February 1, 2009, and August 31, 2013. Ovarian response was categorized by the yield of MII oocytes (low: 1–2; intermediate: 3–6; high: ≥ 7). The main outcome measure was cumulative live birth rate over a 6‐month period. Results Among 250 participants, 3240 oocytes (mean ± SEM 12.96 ± 0.50) were retrieved and there were 152 (60.8%) live births. Overall, 172 (68.8%) participants had a high oocyte yield, 61 (24.4%) an intermediate yield, and 17 (6.8%) a low yield. The cumulative live birth rate was 58.8% (10/17) in the low‐yield group, 55.7% (34/61) in the intermediate‐yield group, and 62.8% (108/172) in the high‐yield group ( P = 0.35). Conclusion In conventional ovarian stimulation, live birth rate is not affected by the ovarian response. Whether oocytes produced from a low ovarian response are biologically more effective than oocytes obtained from a high ovarian response remains to be determined.