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Administering human chorionic gonadotropin injections for triggering follicle maturation could impact fertility during the subsequent menstrual cycle
Author(s) -
Fukuda Junichiro,
Abe Takashi,
Okuno Takashi,
Kobayashi Tamotsu,
Kato Keiichi
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.08.001
Subject(s) - medicine , human chorionic gonadotropin , menstrual cycle , gonadotropin , follicle , fertility , follicle stimulating hormone , andrology , physiology , endocrinology , gynecology , luteinizing hormone , hormone , population , environmental health
Objective To determine whether the use of a human chorionic gonadotropin (hCG) injection as a follicle‐maturation trigger affects a patient's reproductive ability during their subsequent menstrual cycle. Methods Patients that were infertile undergoing natural‐cycle in vitro fertilization at Kato Ladies Clinic, Japan, between March and June 2012 were enrolled in a prospective cohort study. Patients who had received fertility treatments other than hCG injections were excluded from the study. The remaining patients were divided into two cohorts; patients who had received injection‐administered hCG (study group) and patients who had not received any fertility treatment (control group) during their preceding menstrual cycle. The rates of oocyte retrieval, fertilization, clinical pregnancy, and live deliveries were analyzed using a Fisher exact test. Results The rate of successful oocyte‐retrieval ( P < 0.001) and the delivery‐rate ( P = 0.002) were significantly lower in the study group in comparison with the control group. Additionally, the incidence of empty follicles ( P < 0.001) and degenerated oocytes ( P = 0.002) was significantly higher in the exposure group. Conclusion Triggering follicle maturation with hCG during in vitro fertilization could impact patient fertility during their next cycle. Treatment with hCG injection has the potential to influence not only the cycle during which it is administered, but also the subsequent menstrual cycle.