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Clinical characteristics of early‐onset pre‐eclampsia in singleton versus multiple pregnancies
Author(s) -
Ni Yanyan,
Cheng Weiwei
Publication year - 2016
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.07.029
Subject(s) - medicine , eclampsia , singleton , apgar score , obstetrics , pregnancy , fetus , birth weight , incidence (geometry) , umbilical artery , cohort , retrospective cohort study , genetics , physics , optics , biology
Objective To analyze the clinical differences between multiple and singleton pregnancies with early‐onset pre‐eclampsia. Methods The present retrospective cohort study included patients with early‐onset pre‐eclampsia diagnosed at a tertiary hospital in China between January 2012 and June 2014. The patients were divided into a multiple pregnancy group (MP group) and a singleton pregnancy group (SP group). Differences in maternal and fetal outcomes before and after birth were compared between the two groups. Results Overall, 100 patients were included (21 MP group; 79 SP group). The systolic and diastolic blood pressure values at admission were significantly lower in the MP group than in the SP group ( P = 0.032 and P = 0.015, respectively), and the incidence of pregnancy edema was significantly higher ( P = 0.015). Moreover, the mean neonatal birth weight in the MP group was significantly higher than that in the SP group ( P < 0.001). The frequencies of abnormal umbilical arterial resistance score, abnormal fetal heart rate, low birth weight, low Apgar score, neonatal cardiovascular abnormalities, and neonatal infections were significantly lower in multiple pregnancies ( P < 0.05 for all). Conclusion Early‐onset pre‐eclampsia in multiple pregnancies seems to have a protective effect on neonatal survival and improves maternal and fetal outcomes. Disease progression might be delayed when compared with early‐onset pre‐eclampsia in singleton pregnancies.