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Meta‐analysis of oral contraceptive use and risks of all‐cause and cause‐specific death
Author(s) -
Zhong GuoChao,
Cheng JiaHao,
Xu XiangLong,
Wang Kang
Publication year - 2015
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.05.026
Subject(s) - medicine , hazard ratio , breast cancer , cohort study , prospective cohort study , meta analysis , population , mortality rate , gynecology , proportional hazards model , cancer , confidence interval , obstetrics , demography , environmental health , sociology
Abstract Background Whether ever use of oral contraceptives (OCs) is associated with mortality remains unclear. Objectives To evaluate the association between ever use of OCs and mortality. Search strategy On November 2, 2014, PubMed and Embase were searched for human studies, using the terms “contraceptive,” “contraceptives,” “death,” and “mortality.” Selection criteria Prospective cohort studies were included that provided risk estimates on OC use and mortality, and were reported in English or Chinese. Data collection and analysis A random‐effects model was used to pool data. Random‐effects meta‐regression was used to determine whether duration of OC use and time since last OC use were associated with mortality. Main results Nine studies were included. Ever use of OCs was not associated with mortality from all causes (hazard ratio [HR] 0.94; 95% CI 0.87–1.02) or breast cancer (HR 1.00; 95% CI 0.95–1.06). Neither the duration of OC use nor the time since last OC use was associated with all‐cause or breast cancer mortality. In an analysis of a small number of studies, ever users were at decreased risk of mortality from ovarian cancer (HR 0.58; 95% CI 0.35–0.94). Conclusions There is no significant association between ever use of OCs and mortality from all causes or breast cancer.