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Prevalence and genotype distribution of HPV infection among women in Ningbo, China
Author(s) -
Hong Hang,
He Tianfeng,
Ni Hongxia,
Zhang Shu,
Xu Guozhang
Publication year - 2015
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2015.04.027
Subject(s) - medicine , genotyping , hpv infection , genotype , gynecology , sexual intercourse , cervical cancer , obstetrics , population , cancer , environmental health , biochemistry , gene , chemistry
Objective To evaluate HPV prevalence and genotype distribution among women in Ningbo, China. Methods A cluster‐sampling study of women from four randomly selected villages was undertaken between April 1 and June 30, 2012. Married women who were not menstruating and had not had sexual intercourse, used vaginal medications, or performed vaginal douching within the previous 48 hours were enrolled when attending community health centers for family planning appointments. Exfoliated cell specimens were collected for HPV DNA genotyping and cytologic diagnostic tests. Results Among 1373 included women, 185 (13.5%) were found to be HPV positive and 178 (13.0%) had a high‐risk HPV (HR‐HPV) genotype. Among 56 women with cervical cytologic abnormalities, 35 (62.5%) had an HPV infection. The frequency of HPV or HR‐HPV infections rose with increasing severity of cytological abnormalities ( P < 0.001 for both). HPV52 was the most prevalent genotype, followed by HPV58, HPV16, HPV33, and HPV68. An HPV prevalence peak was observed in women aged 40–49 years (101/564 [17.9%]). Conclusion In Ningbo, many women with cervical cytologic abnormalities have HPV infection. Vaccines targeting HPV52 and HPV58 in conjunction with HPV16 and HPV18 are required for the prevention and treatment of cervical lesions in Chinese women.