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Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome
Author(s) -
Baracat Maria Cândida P.,
Serafini Paulo C.,
Simões Ricardo dos S.,
Maciel Gustavo A.R.,
Soares José M.,
Baracat Edmund C.
Publication year - 2015
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2014.10.022
Subject(s) - polycystic ovary , medicine , endometrium , anovulation , estrogen , estrogen receptor , gynecology , estrogen receptor beta , ovary , endocrinology , andrology , insulin resistance , cancer , insulin , breast cancer
Background Infertility associated with polycystic ovary syndrome (PCOS) could be related to many mechanisms including endometrial factors. Objectives To review cell adhesion molecule and estrogen receptor expression in the endometrium. Search strategy A systematic review was performed of the Medline and Cochrane databases for papers published in any language between 2004 and 2014. The search term was “‘polycystic ovary syndrome’ OR ‘Stein Leventhal syndrome’ OR ‘anovulation’ AND ‘endometrium’ OR ‘endometria.’” Selection criteria Research studies on endometrial cell adhesion molecules and estrogen receptor expression among women with PCOS diagnosed according to the Rotterdam criteria were included. Data collection and analysis Data were extracted from identified studies and the quality of assessment was analyzed. Main results Six studies were included. Data were controversial with respect to MUC1 and αVβ3 integrin expression with significantly higher and lower levels, respectively, in women with PCOS. Estrogen receptor expression was enhanced among patients with PCOS as compared with healthy women. Conclusions Endometrial factors influence embryo receptivity as indicated by the molecular mediators identified in the studies, including cell adhesion molecules and the estrogen receptor.