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Prognostic factors of primary fallopian tube cancer in a single institute in Taiwan
Author(s) -
Horng HuannCheng,
Teng SenWen,
Lai ChiungRu,
Chang WenHsu,
Chang YenHou,
Yen MingShyen,
Wang PengHui Peter
Publication year - 2014
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2014.04.018
Subject(s) - medicine , hazard ratio , debulking , stage (stratigraphy) , univariate analysis , lymph node , multivariate analysis , confidence interval , surgery , oncology , cancer , ovarian cancer , gynecology , paleontology , biology
Abstract Objective To improve the understanding of primary fallopian tube carcinoma (PFTC) through an analysis of possible clinical and pathologic determinants of prognosis. Methods A retrospective review of the database of a tertiary hospital in Taiwan for 1978–2007 was conducted to identify patients with a diagnosis of PFTC and to evaluate the clinicopathologic features associated with PFTC outcome. Results Fifty‐eight patients (mean age 62.5 years) had a diagnosis of PFTC. Stage III/IV disease (55%) and poorly differentiated tumors (52%) were most common. The median follow‐up was 93 months (range, 11–333 months). The 5‐year disease‐free survival rate was 59%, and the overall survival rate was 64%. Factors important in disease‐free and overall survival in univariate analysis included the presence of pelvic and/or para‐aortic lymph node metastases, International Federation of Gynecology and Obstetrics stage, high preoperative carbohydrate antigen 125 serum level, completion of optimal debulking surgery, and the use of paclitaxel‐based chemotherapy; however, only patients with optimal cytoreduction had a decreased hazard of recurrence (hazard ratio [HR] 0.06; 95% confidence interval [CI] 0.01–0.23) and mortality (HR 0.08; 95% CI, 0.02–0.31) in multivariate analysis. Conclusion Advanced tumor stage, in particular the presence of lymph node metastases, worsened the prognosis of patients with PFTC. However, optimal debulking surgery significantly improved the prognosis, emphasizing the importance of the treatment strategy.