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Antibiotic susceptibility pattern of genital tract bacteria in pregnant women with preterm premature rupture of membranes in a resource‐limited setting
Author(s) -
Eleje George U.,
Adinma Joseph I.,
Ghasi Samuel,
Ikechebelu Joseph I.,
Igwegbe Anthony O.,
Okonkwo John E.,
Okafor Charles I.,
Ezeama Chukwuemeka O.,
Ezebialu Ifeanyichukwu U.,
Ogbuagu Chukwuanugo N.
Publication year - 2014
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2014.04.016
Subject(s) - cefuroxime , medicine , ampicillin , cefixime , antibiotics , erythromycin , premature rupture of membranes , sulbactam , ceftriaxone , obstetrics , pregnancy , antibiotic resistance , microbiology and biotechnology , gestational age , biology , genetics , imipenem
Objective To identify microbes prevalent in the genital tract of pregnant women with preterm premature rupture of membranes (PPROM) and to assess the susceptibility of the microbial isolates to a range of antibiotics to determine appropriate antibiotics for treating cases of PPROM in resource‐limited settings. Methods A prospective cross‐sectional study was undertaken involving women with (n = 105) and without (n = 105) a confirmed diagnosis of PPROM admitted to Nnamdi Azikiwe University Teaching Hospital, southeast Nigeria, between January 1, 2011, and April 30, 2013. Endocervical swabs were collected from all participants and examined microbiologically. Antibiotic sensitivity testing was performed using Kirby–Bauer disk diffusion. Results Streptococcus spp., Staphylococcus aureus , and Escherichia coli were significantly more prevalent among women with PPROM than among those without PPROM ( P < 0.01). Among the antibiotics considered safe to use during pregnancy, the bacteria were most sensitive to ampicillin‐sulbactam, cefixime, cefuroxime, and erythromycin. Conclusion For the first 48 hours, women with PPROM should receive an intravenous dose combining ampicillin‐sulbactam, cefixime, cefuroxime, or erythromycin with metronidazole followed by oral administration of the chosen antibiotic combination to complete a 7‐day course.