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Distribution of various types of low‐risk human papillomavirus according to cervical cytology and histology in northern Chinese women
Author(s) -
Wei Heng,
Wang Ning,
Zhang Yao,
Zhang Jing,
Wang Shizhuo,
Zhang Shulan
Publication year - 2014
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2014.01.020
Subject(s) - medicine , histology , cytology , human papillomavirus , obstetrics , gynecology , pathology
Objective To describe the distribution of specific types of low‐risk (LR) human papillomavirus (HPV) among a general population of northern Chinese women. Methods Between 2007 and 2012, 118 096 women were tested with the HPV Geno‐Array Test Kit (HybriBio) at China Medical University's Shengjing Affiliated Hospital, Shenyang, China. Among these women, 80 418 underwent cervical cytology and colposcopic examination, and 30 961 of these had a cervical biopsy. The prevalence of HPV infection among the women was analyzed according to age, and cytologic and histologic findings. Results CP8304 was the most common type of LR‐HPV overall, and was most prevalent in the youngest age group. The overall prevalence of LR‐HPV (averaged across all types) was 1.7% in women with normal cytology, 8.8% in those with atypical squamous cells of undetermined significance (ASCUS), 8.0% in those with low‐grade squamous intraepithelial lesions (LSIL), and 5.8% in those with high‐grade squamous intraepithelial lesions (HSIL). LR‐HPV alone, without any high‐risk (HR)‐HPV, was most common among women with ASCUS and cervical intraepithelial neoplasia (CIN) not otherwise specified (CINNOS) together. Co‐infections of LR‐HPV and HR‐HPV were most common among women with LSIL and CIN1. Conclusion These data will facilitate modeling of the cost‐effectiveness of a prophylactic LR‐HPV vaccination in China.