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Maintenance tocolysis with oral micronized progesterone for prevention of preterm birth after arrested preterm labor
Author(s) -
Choudhary Manju,
Suneja Amita,
Vaid Neelam B.,
Guleria Kiran,
Faridi M.M.A.
Publication year - 2014
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2014.01.019
Subject(s) - medicine , exact test , birth weight , obstetrics , pregnancy , placebo , low birth weight , adverse effect , genetics , alternative medicine , pathology , biology
Objective To evaluate the efficacy of maintenance therapy with oral micronized progesterone (OMP) for prolongation of pregnancy in cases of arrested preterm labor. Methods Ninety women at 24–34 weeks of singleton pregnancy with intact membranes and arrested preterm labor were randomly allocated to receive OMP (n = 45) or placebo (n = 45) daily until 37 weeks or delivery, whichever was earlier. Outcome parameters were compared using Student t test, χ 2 test, Fisher exact test, and log‐rank χ 2 test. Results OMP significantly prolonged the latency period (33.29 ± 22.16 vs 23.07 ± 15.42 days; P = 0.013). Log‐rank analysis revealed a significant difference in mean time to delivery between the 2 groups ( P = 0.014). There were significantly fewer preterm births (33% vs 58%; P = 0.034) and low birth weight neonates (37% vs 64%; P = 0.017), and significantly higher mean birth weight (2.44 ± 0.58 vs 2.14 ± 0.47 kg; P = 0.009) in the OMP group. Perinatal outcomes and adverse effects were similar in the 2 groups. Conclusion Maintenance tocolysis with OMP significantly prolonged pregnancy and decreased the number of preterm births. Clinical Trial Registry of India: CTRI/2011/10/002043.