Premium
Endothelial dysfunction after pregnancy‐induced hypertension
Author(s) -
Henriques Ana C.P.T.,
Carvalho Francisco H.C.,
Feitosa Helvécio N.,
Macena Raimunda H.M.,
Mota Rosa M.S.,
Alencar Júlio C.G.
Publication year - 2014
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2013.08.016
Subject(s) - medicine , endothelial dysfunction , pregnancy , obstetrics , biology , genetics
Objective To carry out long‐term analysis of the presence of endothelial dysfunction after the development of pregnancy‐induced hypertension (PIH). Methods In a retrospective cohort study, data were analyzed from 60 women who delivered at a tertiary maternity hospital in Fortaleza, Ceara, Brazil, between 1992 and 2002. Thirty women had a history of PIH and 30 had no history of complications. Anthropometric and laboratory data were collected, and endothelial function was evaluated by flow‐mediated dilatation of the brachial artery. Continuous variables were analyzed via Student t test, and Mann–Whitney test was used to compare means. Clinical and metabolic measures were categorized according to cardiovascular risk by cutoff points determined by national consensus; χ 2 and Fisher exact tests were used to compare the groups. Relative risk was calculated for variables that were statistically significant ( P < 0.05). Results Women with a history of PIH had higher body mass index ( P = 0.03), systolic blood pressure ( P = 0.03), low‐density lipoprotein cholesterol ( P = 0.02), and fasting glucose ( P = 0.02) compared with women with no pregnancy complications. The frequency of endothelial dysfunction was 60% among all women, with a significant difference between the 2 groups ( P = 0.01). Conclusion Women with a history of PIH were found to have a higher frequency of long‐term endothelial dysfunction.