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Hospital‐based prevalence of high‐risk cervical HPV types infecting the general population and female sex workers in Huzhou, China
Author(s) -
Wang Xiang,
Gu Donghua,
Lou Bin,
Xu Bin,
Qian Fuchu,
Chen Yu
Publication year - 2013
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2012.07.019
Subject(s) - medicine , condom , population , hpv infection , female sex , genotyping , demography , gynecology , obstetrics , cervical cancer , virology , genotype , environmental health , syphilis , human immunodeficiency virus (hiv) , cancer , biology , gene , biochemistry , sociology
Objective To evaluate the prevalence of high‐risk HPV types among female sex workers and the general population in Huzhou, China. Methods Cervical samples from the general population (n = 292) and female sex workers (n = 288) in Huzhou, China, were collected between April, 2008, and October, 2009. Demographic, behavioral, and clinical data were obtained by interview. Genotyping of the HPV L1 gene was done via a PGMY09/PGMY11 PCR‐based assay, and the cervical samples were subjected to cytology analysis. Results The prevalence of HPV was higher among female sex workers (66.7%) than among the general population (19.2%). Among female sex workers, HPV‐16 (28.8%) was the most prevalent, followed by HPV‐58 (24.0%) and HPV‐52 (20.8%). The percentage of cervical abnormalities was higher among female sex workers (20.8%) than among the general population (4.8%). Multivariate analysis showed that education level and condom use during coitus were significantly associated with HPV infection ( P < 0.05). HPV‐16, HPV‐58 and HPV‐52 were the dominant types, and were significantly associated with abnormal cervical cytology ( P < 0.05). Conclusion Female sex workers in Huzhou, China, were found to have a greater probability of being infected with high‐risk HPV, and novel vaccines against HPV‐58 and HPV‐52 should be developed. Using condoms could reduce the risk of infection.