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Zygote intrafallopian transfer among patients with repeated implantation failure
Author(s) -
Weissman Ariel,
Horowitz Eran,
Ravhon Amir,
Nahum Hana,
Golan Abraham,
Levran David
Publication year - 2013
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2012.07.018
Subject(s) - medicine , cohort , embryo transfer , retrospective cohort study , in vitro fertilisation , fallopian tube , live birth , assisted reproductive technology , cohort study , gynecology , obstetrics , infertility , surgery , pregnancy , biology , genetics
Objective To summarize the experience of a single center with laparoscopic zygote intrafallopian transfer (ZIFT) performed exclusively among patients with high‐order repeated implantation failure (RIF) following in vitro fertilization‐embryo transfer (IVF‐ET). Methods A retrospective cohort study was performed at the Edith Wolfson Medical Center, a tertiary referral university hospital located in Holon, Israel. A group of 176 patients with 8.15 ± 3.9 previously failed IVF‐ET cycles underwent 280 ZIFT procedures between 1995 and 2010. The main outcome measure was the live birth rate per patient treated. Results In all, there were 274 fresh and 6 frozen ZIFT cycles recorded in the study cohort, resulting in 96 clinical pregnancies per attempt (34.3%) and 72 live births (25.7%). The live birth rate per patient was 39.8%. Conclusion The use of ZIFT remains a powerful tool in the clinical management of selected patients with high‐order RIF. This procedure should be kept in mind when all other measures fail among patients with at least 1 unobstructed fallopian tube.