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Morbidity and pregnancy outcomes associated with sickle cell anemia among Saudi women
Author(s) -
Al Kahtani Maryam A.,
AlQahtani Mohammad,
Alshebaily Mashael M.,
Abd Elzaher Mohamed,
Moawad Ashraf,
AlJohani Naji
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2012.07.008
Subject(s) - medicine , pregnancy , obstetrics , anemia , incidence (geometry) , sickle cell anemia , pediatrics , fetus , disease , genetics , physics , optics , biology
Objective To identify morbidity and pregnancy outcomes associated with sickle cell disease (SCD) among pregnant Saudi women. Methods A 10‐year retrospective study was conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, that included 392 cases of SCD in pregnancy and 784 controls with normal hemoglobin phenotype, who were selected and matched for age, parity, and delivery outcome. The main outcome measures were morbidity, maternal outcomes, and fetal outcomes. Results The incidence of SCD was 1.1% among all deliveries, with 2 maternal deaths (0.5%) and a perinatal mortality rate of 77.7 per 1000 deliveries. The major maternal complications in the SCD group were anemia (86.2%); sickle cell crisis (64.8% overall, with 43.1% vaso‐occlusive, 21.2% hemolytic, and 0.5% sequestration or aplastic); bacterial infection (8.8%); preterm delivery (15.3%); and pre‐eclampsia (9.7%). Fetal growth restriction and stillbirths accounted for 65.6% of the perinatal mortality. Blood transfusion was indicated in 33.7% of pregnancies in the SCD group. Conclusion Pregnant Saudi women with SCD are at increased risk for pregnancy‐related complications, as well as fetal morbidity and mortality. A critical need exists among Saudi hospitals for a multidisciplinary approach to the management of pregnancies complicated by SCD.