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Factors predicting pathologic significance among women with atypical glandular cells on liquid‐based cytology
Author(s) -
Chatchotikawong Usanee,
Ruengkhachorn Irene,
Laiwejpithaya Somsak
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2012.05.027
Subject(s) - histopathology , medicine , incidence (geometry) , cytology , gynecology , odds ratio , confidence interval , cancer , pathology , physics , optics
Objective To determine incidence, originating organ, and factors predicting significant histopathology (premalignant and malignant lesions) among women with atypical glandular cells (AGCs) on liquid‐based cytology (LBC). Methods In a retrospective study at Siriraj Hospital, Bangkok, Thailand, clinical and histologic data were reviewed for women with AGCs who underwent appropriate examinations from January 2007 to December 2010. Results There were 284 women with AGC cytology (mean age, 51.2 years). The incidence of significant pathology and invasive cancer was 43.3% and 34.5%, respectively. The most common malignant organ was the uterus (64/123, 52%). Predictors of serious pathology were AGC favor neoplasia (AGC‐FN) endocervical (odds ratio [OR], 5.64; 95% confidence interval [CI], 1.62–19.57), AGC‐FN endometrial (OR, 4.11; 95% CI, 1.27–13.32), AGC‐FN glandular (OR, 8.23; 95% CI, 2.02–33.49) subtypes, and bleeding (OR, 2.88; 95% CI, 1.47–5.65). Combining patient age and AGC subtype, there were no serious cervical lesions among women aged 50 years or younger with AGC‐FN glandular subtype, or serious non‐cervical neoplasia among women aged 50 years or younger with AGC not otherwise specified (AGC‐NOS) or AGC‐FN endocervical subtypes. Conclusion AGC subcategories defined from LBC, alone or combined with patient age, might be predictors of significant histopathology, cancer incidence, and originating organ.