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A randomized controlled trial comparing ceftriaxone with cefazolin for antibiotic prophylaxis in abdominal hysterectomy
Author(s) -
Phoolcharoen Natacha,
Nilgate Sumanee,
Rattanapuntamanee Orapin,
Limpongsanurak Sompop,
Chaithongwongwatthana Surasith
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2012.04.023
Subject(s) - cefazolin , medicine , ceftriaxone , hysterectomy , surgery , antibiotic prophylaxis , randomized controlled trial , abdominal hysterectomy , incidence (geometry) , premedication , antibiotics , anesthesia , physics , optics , microbiology and biotechnology , biology
Objective To compare the effectiveness of ceftriaxone versus cefazolin for the prevention of febrile morbidity and postoperative infections among patients after abdominal hysterectomy. Methods In a double‐blind, randomized, controlled trial in Bangkok, Thailand, 320 patients undergoing abdominal hysterectomy between July 2008 and July 2009 were randomly assigned to receive 1 g of either ceftriaxone or cefazolin intravenously in a single dose before surgery. The participants were evaluated for postoperative fever and infection for up to 4 weeks. χ 2 or Fisher exact tests were used for statistical analysis. Results There was no significant difference between the ceftriaxone and cefazolin groups in incidence of febrile morbidity (9.4% versus 11.2%), wound infection (3.8% versus 1.9%), vaginal cuff infection (3.8% versus 1.9%), or urinary tract infection (1.9% versus 1.9%). Conclusion There was no difference between the use of single‐dose preoperative ceftriaxone and cefazolin in preventing infectious morbidity among patients undergoing hysterectomy.