Premium
Perinatal outcome in cases of latent syphilis during pregnancy
Author(s) -
Krakauer Yonit,
Pariente Gali,
Sergienko Ruslan,
Wiznitzer Ar,
Sheiner Eyal
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2012.01.026
Subject(s) - medicine , syphilis , latent syphilis , odds ratio , obstetrics , confidence interval , pregnancy , confounding , population , logistic regression , multivariate analysis , immunology , environmental health , human immunodeficiency virus (hiv) , biology , genetics
Objective To investigate factors associated with latent syphilis and pregnancy outcome among women with latent syphilis. Methods A retrospective population‐based study was conducted to compare all pregnancies among women with and without latent syphilis at Soroka University Medical Center, Be'er‐Sheva, Israel, between 1988 and 2010. Stratified analysis using a multiple logistic regression model was performed to control for confounders. Results Of the 219 656 deliveries during the study period, 159 (0.1%) involved women with latent syphilis. Multivariate analysis with backward elimination revealed the following conditions to be significantly associated with latent syphilis: fetal growth restriction (odds ratio [OR] 2.20; 95% confidence interval [CI], 1.07–4.49; P = 0.03); drug abuse (OR 9.95; 95% CI, 1.31–75.46; P = 0.02); tobacco use (OR 3.35; 95% CI, 1.74–6.45; P < 0.05); and Jewish (vs Bedouin) ethnicity (OR 4.05; 95% CI, 2.65–6.20; P < 0.05). Conclusion Women with latent syphilis are at risk for adverse maternal and perinatal outcomes, including fetal growth restriction. Careful surveillance of these high‐risk pregnancies should be considered.