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The value of fallopian tube sperm perfusion in the management of mild–moderate male factor infertility
Author(s) -
ElKhayat Waleed,
ElMazny Akmal,
AbouSalem Nermeen,
Moafy Aly
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.11.023
Subject(s) - medicine , gynecology , fallopian tube , infertility , pregnancy rate , pregnancy , ectopic pregnancy , insemination , sperm , obstetrics , unexplained infertility , andrology , genetics , biology
Objective To investigate whether fallopian tube sperm perfusion (FSP) would improve pregnancy rates compared with standard intrauterine insemination (IUI) in cases of male factor infertility. Methods In a randomized controlled trial at a university teaching hospital in Egypt, 120 couples with mild or moderate male factor infertility underwent a mild controlled ovarian stimulation protocol (clomiphene citrate plus human menopausal gonadotropin). Women were randomly allocated to group 1 (FSP via Foley catheter with 4 mL of inseminate) or group 2 (standard IUI with 0.5 mL of inseminate) (n = 60 for both). The main outcome measure was clinical pregnancy rate. Results There were no significant differences between the groups in terms of baseline clinical characteristics, semen parameters, or characteristics of stimulation cycles. The pregnancy rate was significantly higher in group 1 than in group 2 (16 [26.7%] vs 7 [11.7%]; P < 0.04). There was no significant difference in the incidence of multiple pregnancy, abortion, or ectopic pregnancy between the groups. Conclusion Fallopian tube sperm perfusion is an effective technique in the management of mild–moderate male factor infertility and should, therefore, be considered before resorting to more sophisticated techniques of assisted reproduction.