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A multicenter study of the clinical characteristics of usual‐type vulvar intraepithelial neoplasia in China
Author(s) -
Li Xiaochuan,
Zhu Lan,
Gu Yu,
Jin Hangmei,
Wang Changyu,
Lang Jinghe
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.11.008
Subject(s) - medicine , vulvar intraepithelial neoplasia , anus , vagina , intraepithelial neoplasia , vulva , cervical intraepithelial neoplasia , sex organ , retrospective cohort study , dermatology , pathology , surgery , cervical cancer , prostate , cancer , biology , genetics
Objective To investigate clinical characteristics of usual‐type vulvar intraepithelial neoplasia (uVIN) in China. Methods A retrospective review of the records of 64 patients with uVIN was performed at 3 academic hospitals between 2004 and 2010. Patients were assigned to a younger (≤ 40 years) or an older (> 40 years) group. Clinical characteristics of lesions were described and analyzed. Results Mean patient age was 40.6 years. There was a high proportion of incidental findings (34%), multifocal lesions (64%), variegated lesions (59%), and multiple neoplastic lesions in the lower genital tract (20%). As patient age increased, so did numbers of patients reporting pain ( P < 0.05). Longer time between symptom onset and uVIN diagnosis, and more multifocal lesions were noted in the older group ( P < 0.05). Whereas younger patients often presented with cervical intraepithelial neoplasia and uVIN, older patients often presented with intraepithelial neoplasia at uncommon locations (e.g. vagina, anus, and periurethral region) ( P < 0.05). No differences between the groups were found regarding gross appearance or anatomic location of uVIN lesions ( P > 0.05). Conclusion Age‐specific differences were noted in location of neoplastic lesions in the lower genital tract and time to diagnosis of uVIN. However, the clinical features of uVIN lesions were heterogeneous and non‐age specific.