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Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy
Author(s) -
FigueiróFilho Ernesto A.,
Oliveira Myrna L.G.,
Pompilio Maurício A.,
Uehara Silvia N.O.,
Coelho Lílian R.,
De Souza Bruno A.,
Breda Ili
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.10.026
Subject(s) - medicine , oseltamivir , pregnancy , odds ratio , confidence interval , medical record , obstetrics , pediatrics , h1n1 pandemic , cross sectional study , covid-19 , disease , infectious disease (medical specialty) , pathology , biology , genetics
Objective To determine perinatal outcome and epidemiologic, clinical, and obstetric characteristics among pregnant women infected with the H1N1 virus admitted to a Brazilian university hospital. Methods A cross‐sectional study was conducted of pregnant women infected with H1N1 who were admitted to the University Hospital at the School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil, during the 2009 pandemic. Data were obtained via a questionnaire, which was administered during the hospital evaluation of patients’ medical records. Results Thirty‐one patients were included in the study. Antiviral therapy was initiated within 48 hours of the onset of symptoms in 64.5% of cases. Infection with the H1N1 virus was associated with severe clinical complications in 22.6% of patients and adverse perinatal outcomes in 41.9% of cases. The rate of maternal and perinatal mortality was 9.7%. There was a statistically significant association between late treatment with oseltamivir and increase in systemic complications in pregnancy (odds ratio 22.80 [95% confidence interval, 2.20–235.65]; P = 0.007). Conclusion Early treatment with oseltamivir may prevent serious complications associated with H1N1 infection in pregnant women but it does not affect perinatal outcome.