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Effects of domperidone on augmentation of lactation following cesarean delivery at full term
Author(s) -
Jantarasaengaram Surasak,
Sreewapa Praweena
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.10.019
Subject(s) - domperidone , medicine , placebo , adverse effect , lactation , breast milk , anesthesia , pregnancy , chemistry , biology , alternative medicine , pathology , genetics , dopamine , biochemistry
Objective To evaluate the effects of domperidone on breast milk production in women who underwent cesarean at full term. Methods Women who underwent uncomplicated full‐term cesarean were randomly assigned to receive domperidone or placebo for 4 consecutive days post partum. Breast milk was collected twice daily via electric breast pump. Baseline milk production was determined by measuring the volume of milk collected on the 1st postpartum day, before initiation of study medication (day 0). The daily volume of milk collected was compared between groups. Adverse treatment‐related effects were recorded. Results The study was completed by 22 women in the domperidone group and 23 in the placebo group. Compared with day 0, mean increases in milk volume per participant collected on days 1, 2, 3, and 4 were significantly higher in the domperidone (13.6 ± 23.2 mL, 68.5 ± 71.9 mL, 144.5 ± 122.3 mL, and 191.3 ± 136.1 mL) than in the placebo (2.5 ± 4.6 mL, 24.5 ± 26.5 mL, 72.1 ± 55.6 mL, and 91.4 ± 60.3 mL) group. Minor adverse effects were reported by 7 women in the domperidone group. Conclusion Postpartum treatment with domperidone can augment breast milk production after full‐term cesarean, with minimal adverse effects.