Premium
Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China
Author(s) -
Du MingMei,
Jia Na,
Suo JiJiang,
Xing YuBin,
Zhang PanHe,
Liu Gang,
Xiao HongJu,
Zhang JiuSong,
Jia Ning,
Gao Yan,
Xie LiJun,
Deng ChunYan,
Ren ShiWang,
Liu YunXi
Publication year - 2012
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.08.024
Subject(s) - medicine , pregnancy , pandemic , obstetrics , offspring , virus , beijing , influenza a virus , fetus , pediatrics , covid-19 , immunology , china , disease , genetics , political science , law , infectious disease (medical specialty) , biology
Objective To investigate the pregnancy complications, perinatal outcomes, and congenital abnormalities (CAs) that occurred in Beijing, China, when pregnant women became infected with the 2009 pandemic influenza A (H1N1) (H1N1pdm). Methods Pregnancy complications, perinatal outcomes, and CAs were compared among 3 groups of pregnant women. The 23 women in group 1 were confirmed to harbor viral RNA; the 23 in group 2 had serum levels of virus‐specific antibodies against H1N1pdm, meaning that they were suspected of being infected with the virus; and the 93 in group 3 had no detectable virus‐specific antibodies. Results Perinatal outcomes and pregnancy complications were not significantly different in groups 1 and 3. Higher percentages of stillbirths (12.0%) and placental disorders (13.0%) were observed in group 2 than in group 3. Many women in group 2 (62.5%) experienced symptoms of having a cold during pregnancy and most took no medication. Two cases of CA occurred in group 1, in the offspring of women infected in the second trimester. Conclusion When left untreated, infection with the 2009 H1N1pdm virus during pregnancy appears to have increased fetal mortality and morbidity. Because CAs are traumatic for all concerned, their possible association with the virus should be further evaluated.