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Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery
Author(s) -
Movafegh Ali,
Eslamian Laleh,
Dorabadi Azita
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.07.015
Subject(s) - tranexamic acid , blood loss , cesarean delivery , medicine , anesthesia , administration (probate law) , pregnancy , surgery , biology , political science , law , genetics
Objective To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery. Methods One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double‐blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded. Results The patients’ mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P < 0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P = 0.001). Conclusion Intravenous tranexamic acid decreased intra‐ and postoperative blood loss and oxytocin administered in patients delivered by cesarean.