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Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery
Author(s) -
Movafegh Ali,
Eslamian Laleh,
Dorabadi Azita
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.07.015
Subject(s) - tranexamic acid , blood loss , cesarean delivery , medicine , anesthesia , administration (probate law) , pregnancy , surgery , biology , political science , law , genetics
Abstract Objective To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery. Methods One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double‐blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded. Results The patients’ mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P < 0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P = 0.001). Conclusion Intravenous tranexamic acid decreased intra‐ and postoperative blood loss and oxytocin administered in patients delivered by cesarean.