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The combination of mifepristone and misoprostol for the termination of pregnancy
Author(s) -
Faúndes Anibal
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.07.013
Subject(s) - misoprostol , mifepristone , medicine , obstetrics , medical abortion , gestation , abortion , pregnancy , gestational age , regimen , fetus , abortifacient , induction of labor , gynecology , surgery , genetics , biology
The combination of 200 mg of mifepristone followed by 25 μg to 800 μg (depending on gestational age) of misoprostol has been shown to be effective for the termination of pregnancy throughout gestation. The dose of misoprostol should be reduced as gestational age increases. Mifepristone is not indicated for induction of labor with a live fetus because there are no data to confirm that it does not have a possible deleterious fetal effect. The course of treatment and prerequisites for medical abortion and recommended mifepristone and misoprostol regimens for different gestational ages are described, along with the side effects, management of complications, and postabortion care. The use of the mifepristone–misoprostol combination regimen for induction of labor in cases of fetal death is also described.