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Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women
Author(s) -
Denslow Sheri A.,
Westreich Daniel J.,
Firnhaber Cynthia,
Michelow Pam,
Williams Sophie,
Smith Jennifer S.
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2011.03.011
Subject(s) - bacterial vaginosis , squamous intraepithelial lesion , medicine , confidence interval , cervical cancer , risk factor , gynecology , prospective cohort study , rate ratio , obstetrics , cervical intraepithelial neoplasia , cancer
Objective To assess the effect of bacterial vaginosis (BV) on the risk of high‐grade squamous intraepithelial lesions (HSIL) among HIV‐seropositive women. Methods A hospital‐based prospective cohort study of HIV‐seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log‐binomial and Poisson regressions were used to estimate prevalence and rate ratios, respectively. Results Among 1954 HIV‐seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalence of HSIL (adjusted prevalence ratio, 1.12; 95% confidence intervals (CI), 0.92–1.35) nor with cervical lesion progression at follow‐up visit (n = 503) (adjusted rate ratio: 1.00; 95% CI, 0.65–1.53). Conclusion Among HIV‐seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression.