Premium
Impact of hot flashes and night sweats on carotid intima–media thickness and bone mineral density among postmenopausal women
Author(s) -
Özkaya Enis,
Cakir Evrim,
Kara Fadil,
Okuyan Erhan,
Cakir Caner,
Üstün Gülnihal,
Küçüközkan Tuncay
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.12.020
Subject(s) - medicine , vasomotor , odds ratio , asymptomatic , bone mineral , menopause , confidence interval , body mass index , osteoporosis
Objective To determine whether postmenopausal women with vasomotor symptoms have a lower bone mineral density (BMD) and a higher carotid intima–media thickness (CIMT) than those without vasomotor symptoms. Methods Postmenopausal women with (n = 87) or without (n = 117) vasomotor symptoms who did not receive hormone therapy were included. The CIMT and BMD were determined and the relationship with vasomotor symptoms evaluated. Results The presence of both hot flashes and night sweats was associated with a CIMT of more than 0.80 mm after adjusting for age, time since menopause, and body mass index (adjusted odds ratio 3.2; 95% confidence interval [CI], 2.3–4.5; P < 0.001). The adjusted odds ratio for a CIMT higher than 0.80 mm in women with night sweats was 3.6 (95% CI 1.5–8.9; P = 0.006); the adjusted odds ratio in women with hot flashes was 23.1 (95% CI 9.1–58.4; P < 0.001). The mean CIMT was 0.65 ± 0.08 mm in the asymptomatic group and 0.81 ± 0.06 mm in the symptomatic group ( P < 0.001). The mean lumbar (L1, L2, and L3) and total hip BMD values were lower in the symptomatic group ( P < 0.05). Conclusion Hot flashes and night sweats in postmenopausal women are associated with a higher CIMT and a lower BMD.