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Polycystic ovary syndrome and increased polyp numbers as risk factors for malignant transformation of endometrial polyps in premenopausal women
Author(s) -
Kilicdag Esra B.,
Haydardedeoglu Bulent,
Cok Tayfun,
Parlakgumus Ayse H.,
Simsek Erhan,
Bolat Filiz A.
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.10.014
Subject(s) - medicine , endometrial polyp , malignancy , polycystic ovary , malignant transformation , gynecology , endometrium , retrospective cohort study , ovary , gastroenterology , hysteroscopy , pathology , obesity , insulin resistance
Objective To determine the pre‐malignant and malignant potential of endometrial polyps and to assess whether different clinical parameters are associated with malignancy in the polyps of premenopausal women. Methods The clinical records of operative office hysteroscopic and resectoscopic procedures for endometrial polyps in 417 premenopausal women who attended Baskent University were examined over a retrospective period of 30 months. Only premenopausal patients were included in the study. Results In 97.8% of women, histology showed benign endometrial pathology. In 2.2% of women, pre‐malignant or malignant conditions were found in the polyp. Polycystic ovary syndrome (PCOS) and the presence of 2 or more polyps were associated with significant pre‐malignant or malignant changes. Conclusion The presence of irregular vaginal bleeding was not a predictor of malignancy in the polyp. Premenopausal women with PCOS and those with 2 or more polyps had an increased prevalence of polyp malignancy. These groups of patients, whether symptomatic or not, should be evaluated by hysteroscopic resection of the polyps.