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Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high‐grade precancerous lesions in Chengdu, western China
Author(s) -
Li Jinke,
Zhang Dan,
Zhang Yi,
Wang Xia,
Lin Yong,
Hu Lina
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.08.010
Subject(s) - medicine , genotype , cervical cancer , human papillomavirus , oncology , hpv infection , gynecology , cancer , obstetrics , gene , genetics , biology
Objective To study the prevalence and genotype distribution of human papillomavirus (HPV) among women with cervical cancer or high‐grade squamous intraepithelial lesions (HSIL) in western China. Methods Cervical cast‐off cells from 144 women with cervical cancer and 63 women with HSIL were tested for HPV genotypes using an oligonucleotide microarray. Results The overall HPV prevalence was 80.6% in cases of carcinoma and 61.9% in cases of HSIL. The most common genotypes were HPV‐16 (carcinoma, 68.1%; HSIL, 34.9%) and HPV‐58 (carcinoma, 8.3%; HSIL, 17.5%). Other high‐risk types included HPV‐18, −31, −33, −35, −45, and −52, with HPV‐18 more common in adenocarcinomas than in squamous cell carcinomas (21.4% vs 3.1%; P < 0.02). The HPV prevalence was lower among patients older than 49 years ( P < 0.02). Conclusion The prevalence of HPV‐16 and HPV‐58 was high. This finding may help to improve HPV vaccination and cervical cancer prevention programs in western China.