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CYP1A1 polymorphism in adolescents with polycystic ovary syndrome
Author(s) -
Akgül Sinem,
Derman Orhan,
Alikaşifoğlu Mehmet,
Aktaş Dilek
Publication year - 2011
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.07.032
Subject(s) - medicine , polycystic ovary , polymorphism (computer science) , gynecology , genetics , endocrinology , allele , gene , insulin resistance , obesity , biology
Objective To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females. Methods The CYP1A1 Ile/Val polymorphism was analyzed by collecting DNA samples from 44 adolescents with polycystic ovary syndrome (PCOS)—according to the Rotterdam criteria—and 120 healthy female controls aged 13–18 years in Ankara, Turkey. Results There was a 2.5‐fold increase in the frequency of the CYP1A1 Ile/Val genotype in adolescents with PCOS compared with the control group (odds ratio [OR] 2.54; 95% confidence interval [CI], 1.143–5.637; P < 0.001), in addition to a 2.4‐fold increase in the frequency of the Val allele (OR 2.43; 95% CI, 1.099–5.397; P < 0.001). Conclusion The data show an association between CYP1A1 and PCOS, indicating that variant alleles of the gene may affect the metabolic and transport pathway of estrogens, thus causing PCOS.