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Natural history of infections with high‐risk HPV in Chinese women with abnormal cervical cytology findings at baseline
Author(s) -
Guo Yanli,
You Ke,
Qiao Jie,
Zhao Yiming,
Liu Congrong,
Geng Li
Publication year - 2010
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.03.021
Subject(s) - medicine , natural history , cervical intraepithelial neoplasia , viral load , cytology , prospective cohort study , human papillomavirus , natural history study , gynecology , cervical cancer , virus , pathology , immunology , cancer
Objective To clarify the natural history of disease in Chinese women with benign cytologic observation and positive for high‐risk human papillomavirus (HR‐HPV). Method From September 1, 2004, to June 30, 2008, this prospective study followed up 893 women positive for HR‐HPV who also had benign cytologic findings at baseline. Results After 3 to 57 months, the viral clearance rate was higher for patients younger than 30 years and for patients who had a low viral load at baseline than for those in their comparison groups. Conversely, the occurrence rate of cervical intraepithelial neoplasia (CIN) 2 or 3 was higher for patients with persistent HR‐HPV infection, those who had CIN 1 at baseline, and those whose the second viral load was increased. Conclusion Age, viral load, and presence of CIN 1 at the first evaluation were the main factors affecting the natural history of HR‐HPV infection in women with benign baseline cytologic findings. The result(s) of the second HR‐HPV testing were independent indicators of histologic progression.