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Efficacy of mifepristone in reducing intermenstrual vaginal bleeding in users of the levonorgestrel intrauterine system
Author(s) -
Lal Suman,
Kriplani Alka,
Kulshrestha Vidushi,
Sharma Meenakshi,
Agarwal Nutan
Publication year - 2010
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.01.015
Subject(s) - medicine , mifepristone , levonorgestrel , breakthrough bleeding , gynecology , menstruation , vaginal bleeding , obstetrics , population , surgery , research methodology , family planning , pregnancy , genetics , environmental health , biology
Objective To evaluate the efficacy of mifepristone to reduce intermenstrual bleeding in levonorgestrel intrauterine system (LNG‐IUS) users. Method In this prospective, open‐label, comparative study, 36 women using the LNG‐IUS for menorrhagia received 100 mg of mifepristone every 30 days for 3 months (group 1). Fifty age‐matched LNG‐IUS users who did not receive any drugs were used as the comparison group (group 2). Menstrual bleeding days, pictorial blood loss assessment chart (PBAC) score, and intermenstrual bleeding/spotting days were compared between the 2 groups at 3 months (during treatment) and at 6 months (3 months post treatment). Results Baseline characteristics were comparable between the groups. At 3 months, median duration and episodes of intermenstrual bleeding/spotting were significantly lower in group 1 compared with group 2 (6 vs 12.5 days, P = 0.01; 2.5 vs 3, P = 0.05, respectively). More women were satisfied with the LNG‐IUS in the mifepristone group compared with the control group (75% vs 44%; P = 0.004). At 6 months, the median duration of intermenstrual bleeding/spotting was significantly lower in group 1 compared with group 2 (6 vs 15 days; P = 0.008). Conclusion Mifepristone was effective in reducing the number of episodes and duration of intermenstrual bleeding/spotting in LNG‐IUS users.