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Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome
Author(s) -
ElMazny Akmal,
AbouSalem Nermeen,
ElSherbiny Walid,
ElMazny Ahmed
Publication year - 2010
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2010.01.014
Subject(s) - dyslipidemia , insulin resistance , polycystic ovary , medicine , hypertriglyceridemia , endocrinology , metabolic syndrome , insulin , triglyceride , obesity , cholesterol
Objective To investigate the association of insulin resistance with dyslipidemia and metabolic syndrome (MBS) in women with polycystic ovary syndrome (PCOS). Methods Fasting glucose (G), insulin (I), and lipid levels were measured in 50 infertile women with PCOS. A fasting G/I ratio of 4.5 or less (n = 29) defined insulin resistance (IR). Results The mean levels of total cholesterol ( P < 0.001), low‐density lipoprotein ( P = 0.02), and triglycerides ( P < 0.001) were significantly higher and the mean levels of high‐density lipoprotein were significantly lower ( P < 0.001) in the IR group. The prevalence of MBS ( P = 0.02) and obesity ( P = 0.04), hypertension ( P = 0.02), fasting hyperglycemia ( P = 0.03), low high‐density lipoprotein levels ( P = 0.02), and hypertriglyceridemia ( P = 0.02) were also significantly higher in the IR group. Conclusion Insulin resistance is associated with dyslipidemia and MBS in women with PCOS. Lifestyle modification and insulin‐sensitizing agents should be part of the management plan.