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Clomiphene citrate plus tamoxifen versus laparoscopic ovarian drilling in women with clomiphene‐resistant polycystic ovary syndrome
Author(s) -
Zakherah Mahmoud S.,
Nasr Ahmed,
El Saman Aly M.,
Shaaban Omar M.,
Shahin Ahmed Y.
Publication year - 2010
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.10.004
Subject(s) - medicine , polycystic ovary , gynecology , ovary , clomifene , insulin resistance , insulin
Objective To compare the efficacy of clomiphene citrate (CC) plus tamoxifen with that of laparoscopic ovarian drilling in clomiphene‐resistant women with polycystic ovary syndrome (PCOS). Method We randomly allocated 150 women with CC‐resistant PCOS to a combined medication group (group 1) or a laparoscopic surgery group (group 2). The primary outcome was the live birth rate in each group; secondary outcomes were the rates of ovulation, clinical pregnancy and miscarriage. Results There were no significant differences between the groups regarding rates of ovulation (81.3% vs 85.3%), pregnancy (53.3% vs 50.7%), or live births (49.3% vs 44.0%), but the mean endometrium thickness was significantly greater on the day of human chorionic gonadotropin administration in group 1 ( P < 0.001). Conclusion Clomiphene citrate plus tamoxifen was as effective as laparoscopic ovarian drilling in promoting ovulation and pregnancy.