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Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia
Author(s) -
Aboud Said,
Msamanga Gernard,
Read Jennifer S.,
Wang Lei,
Mfalila Chelu,
Sharma Usha,
Martinson Francis,
Taha Taha E.,
Goldenberg Robert L.,
Fawzi Wafaie W.
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.07.037
Subject(s) - medicine , tanzania , pregnancy , placebo , obstetrics , prenatal care , antibiotics , cohort , pediatrics , gestation , population , environmental health , genetics , alternative medicine , environmental science , environmental planning , pathology , microbiology and biotechnology , biology
Objective We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV‐infected and uninfected women. Methods A multicenter trial was conducted at clinical sites in 4 Sub‐Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV‐infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20–24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26–30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1‐week course was completed. Logistic regression and Cox proportional hazards models were used. Results There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV‐infected or the uninfected cohort. Conclusion Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV‐infected and uninfected pregnant women.