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Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome
Author(s) -
Ashrafinia Mansoor,
Hosseini Reihaneh,
Moini Ashraf,
Eslami Bita,
Asgari Zahra
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.06.022
Subject(s) - medicine , metformin , polycystic ovary , hirsutism , luteinizing hormone , infertility , odds ratio , gynecology , urology , insulin resistance , randomized controlled trial , gastroenterology , endocrinology , hormone , insulin , pregnancy , biology , genetics
Objective To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow‐up. Methods A randomized trial was conducted in 126 patients with PCOS who had a history of infertility for at least 1 year and resistance to clomiphene citrate (CC). Patients (n = 63) received metformin treatment or underwent LOD (n = 63). Results Levels of follicle‐stimulating hormone did not change in either group after the intervention ( P > 0.05). Serum levels of testosterone ( P < 0.001) and luteinizing hormone ( P < 0.001) were significantly lower after the treatment in both groups. The proportion of women with regular menstrual cycles increased significantly to 35% ( P < 0.001) in the LOD group and to 49% ( P < 0.001) in metformin group compared with before the intervention. Although proportion was higher in the metformin group compared with the LOD group, the difference was not significant (odds ratio 1.81; 95% CI, 0.88–3.69, P = 0.1). Hirsutism decreased significantly from 100% to 79.37% ( P < 0.001) in both groups. Conclusion CC‐resistant patients with PCOS were treated effectively by both metformin and LOD.