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Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands
Author(s) -
Benito Virginia,
Lubrano Amina,
Arencibia Octavio,
Andújar Miguel,
Álvarez Eva,
Mediorberto,
Falcón Juan Miguel,
Falcón Orlando
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.05.020
Subject(s) - medicine , histology , stage (stratigraphy) , multivariate analysis , endometrial stromal sarcoma , leiomyosarcoma , survival analysis , survival rate , sarcoma , adenocarcinoma , proportional hazards model , gynecology , oncology , uterus , pathology , cancer , biology , paleontology
Objective To evaluate the clinicopathologic data and prognostic factors for patients with uterine sarcomas treated at a single institution, with special emphasis on malignant mixed müllerian tumors (MMMT). Methods Medical and anatomic pathology records were reviewed. Survival rates were analyzed using the Kaplan‐Meier method. Results The study included 89 patients: 48.4% with MMMT; 22.4% with leiomyosarcomas; 20.2% with endometrial stromal sarcomas; and 9% with adenosarcomas. FIGO stages I, II, III, and IV were identified in 57.3%, 9.0%, 22.5%, and 7.8% of patients respectively. Event‐free survival rates after 2, 5, and 10 years were 70%, 61%, and 55% respectively, with a median time of 90 months (95% CI, 41–140 months). Overall survival rates after 2, 5, and 10 years were 50%, 45%, and 39% respectively, with a median time of 43 months (95% CI, 3–83 months). Multivariate analysis showed that stage, histology, tumor size, and parity had an independent influence on overall survival. Conclusions MMMT are the most aggressive tumors and their behavior strongly resembles that of high‐grade endometrial adenocarcinoma. Prognostic factors affecting survival were stage, histology, tumor size, and parity.