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Adverse effects of combined spinal–epidural versus traditional epidural analgesia during labor
Author(s) -
Skupski Daniel W.,
Abramovitz Sharon,
Samuels Jon,
Pressimone Vanessa,
Kjaer Klaus
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.04.019
Subject(s) - medicine , anesthesia , adverse effect , visual analogue scale , labor pain , combined spinal epidural , fetal heart rate , randomized controlled trial , randomization , heart rate , cesarean delivery , pregnancy , surgery , blood pressure , biology , genetics
Objective To compare two neuraxial block techniques during labor for maternal and fetal effects. Methods Women in labor at term with cephalic singleton fetuses were randomized (nonblinded) to receive either labor epidural (EPI) or combined spinal–epidural (CSE) analgesia. Primary outcome was prolonged deceleration (PD) of fetal heart rate. Outcomes also included hypotension, mode of delivery, and efficacy of analgesia by visual analog pain scale (VAPS) before and after block placement. Results Randomization occurred in 127 patients: 63 received EPI, 64 received CSE. There was no difference in the rate of PD in the EPI group compared with the CSE group (3.2% vs 6.2% respectively; P = 0.43, RR 2.0; 95% CI 0.4–9.3), rate of cesarean delivery, or mean epidural duration. VAPS ratings were significantly lower in the CSE group. Conclusions There were no differences in the rate of PD or other adverse outcomes. Hypotension occurred more frequently with CSE during labor at term. The study supports both EPI and CSE during labor as safe and effective techniques for neuraxial analgesia.