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Low‐dose propofol to prevent nausea and vomiting after laparoscopic surgery
Author(s) -
Fujii Yoshitaka,
Itakura Michiyo
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.03.008
Subject(s) - retching , medicine , nausea , propofol , vomiting , anesthesia , placebo , postoperative nausea and vomiting , adverse effect , antiemetic , surgery , alternative medicine , pathology
Objective To evaluate the efficacy of administering a low dose of propofol at the end of surgery in preventing postoperative nausea/vomiting in women undergoing gynecologic laparoscopic surgery. Method In a randomized, double‐blind, placebo‐controlled study, 90 patients received intravenous injections of a placebo or propofol at 2 different low doses, 0.25 mg/kg or 0.5 mg/kg. All episodes of nausea, retching, or vomiting were then recorded for 24 hours. Results The percentages of patients experiencing nausea, retching, or vomiting were 67% in the placebo group, 60% in the propofol 0.25 mg/kg group ( P = 0.39), and 33% in the propofol 0.5 mg/kg group ( P = 0.009). A significant difference in the rates of nausea/vomiting was found between the 2 propofol groups ( P = 0.03). No adverse events attributed to the study drug were observed. Conclusion Prophylactic therapy with 0.5 mg/kg of propofol was found to be effective in preventing nausea/vomiting in patients undergoing gynecologic laparoscopic surgery.