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Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome
Author(s) -
Khajehei Marjan,
Abdali Khadijeh,
Parsanezhad Mohammad Ebrahim,
Tabatabaee Hamid Reza
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2009.01.016
Subject(s) - dydrogesterone , placebo , medicine , vitamin d and neurology , calcium , randomized controlled trial , vitamin , menstrual cycle , hormone , estrogen , alternative medicine , pathology
Objective To compare the effects of dydrogesterone and calcium plus vitamin D in women with severe premenstrual syndrome (PMS). Method In this randomized, double‐blind, placebo‐controlled study, 180 Shiraz University students with PMS used questionnaires daily to rate their symptoms for 2 menstrual cycles. Then, the students were randomly assigned to take a tablet containing either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of the cycle for 2 more cycles, and to use the same questionnaires during the intervention cycles. The collected data were then analyzed by repeated‐measurement design and multilevel modeling tests. Result Treatment with dydrogesterone or calcium plus vitamin D decreased symptom severity in a similar way (by 4.64% and 4.20%, respectively) and placebo was associated with a 3.42% decrease. Conclusion Treatment with dydrogesterone or calcium plus vitamin D had a similar effect on symptom severity in women with PMS.