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Coenzyme Q10 supplementation during pregnancy reduces the risk of pre‐eclampsia
Author(s) -
Teran Enrique,
Hernandez Isabel,
Nieto Belen,
Tavara Rosio,
Ocampo Juan Emilio,
Calle Andres
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.11.033
Subject(s) - eclampsia , coenzyme q10 , medicine , placebo , pregnancy , relative risk , confidence interval , obstetrics , randomized controlled trial , biology , genetics , alternative medicine , pathology
Objective To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre‐eclampsia. Methods Women at increased risk of pre‐eclampsia were enrolled in a randomized, double‐blind, placebo‐controlled trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre‐eclampsia. Statistical analyses were by intention‐to‐treat. Results Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed‐up. The overall rate of pre‐eclampsia was 20% (n = 47). Thirty women (25.6%) in the placebo group developed pre‐eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant ( P = 0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33–0.96). Conclusion Supplementation with CoQ10 reduces the risk of developing pre‐eclampsia in women at risk for the condition.