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Polycystic ovary syndrome and abnormalities in glucose tolerance
Author(s) -
Bhattacharya Sudhindra M.
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.11.031
Subject(s) - medicine , polycystic ovary , endocrinology , insulin resistance , impaired glucose tolerance , body mass index , testosterone (patch) , glucose tolerance test , insulin , hyperandrogenism , ingestion , waist–hip ratio , waist
Objectives To compare the prevalence of abnormal glucose tolerance (AGT) among women with polycystic ovary syndrome (PCOS) and controls, and assess risk factors associated with PCOS. Method A fasting oral glucose tolerance test after ingestion of 75 g of glucose was administered to 264 women with and 116 without PCOS. Moreover, fasting glucose, insulin, and testosterone levels were measured in the women with PCOS. Body mass index (BMI), waist‐to‐hip ratio (WHR), and homeostasis model assessment–insulin resistance (HOMA‐IR) were calculated for each woman with PCOS. Results The AGT prevalence was 14.4% in the PCOS group and 11.2% in the control group ( P = 0.17). The women with both PCOS and AGT had significantly higher BMIs, WHRs, testosterone levels, and HOMA‐IR values than those with normal glucose tolerance. Conclusion While AGT was not associated with PCOS, the women with both PCOS and AGT were significantly more obese, hyperandrogenic, and insulin resistant than those with PCOS and normal glucose tolerance.